![]() Epidermodysplasia verruciformisĮpidermodysplasia verruciformis is a rare autosomal recessive condition susceptible to skin infection with specific HPV types that cause flat pityriasis versicolor-like lesions and squamous cell carcinoma. They clinically resemble common warts and tend to be numerous. Autoinoculation of the virus in a scratch can result in a line of warts (pseudo-koebnerisation) The incubation period can be as long as twelve months, depending on the amount of virus inoculated.īutcher's warts are specifically caused by HPV 7 infecting the hands of butchers and others whose occupation involves chronic exposure to a cold moist environment. HPV is spread by direct skin-to-skin contact or autoinoculation if a wart is scratched or picked, a wart may develop under the fingernail ( subungual wart) or virus may be spread to another area of skin. The most common HPV types infecting the skin are types 1, 2, 3, 4, 10, 27, 29, and 57. ![]() Infection begins in the basal layer of the epidermis, causing proliferation of the keratinocytes (skin cells) and hyperkeratosis, and production of infectious virus particles - the wart. There are more than 150 known HPV types, only some of which infect the skin, giving rise to a variety of clinical presentations. Warts are due to infection by the human papillomavirus (HPV), a double-stranded DNA virus.
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